Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | PBK | Q96KB5 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423748 | 1.00 | KMT2A (0.60) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| SCHEMBL8719751 | 1.00 | KMT2A (0.60) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| SCHEMBL5094284 | 0.91 | NAMPT (0.63) | KMT2ANAMPTSMN1; SMN2HPGDCTSL | |
| SCHEMBL13325381 | 0.91 | NAMPT (0.63) | KMT2ANAMPTSMN1; SMN2HPGDCTSL | |
| SCHEMBL13325386 | 0.91 | NAMPT (0.63) | KMT2ANAMPTSMN1; SMN2HPGDCTSL | |
| Mandelic Acid SCHEMBL8716945 | 0.89 | KMT2A (0.50) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| Mandelic Acid SCHEMBL7303904 | 0.89 | KMT2A (0.50) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| Mandelic Acid SCHEMBL7297870 | 0.89 | KMT2A (0.50) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| Mandelic Acid SCHEMBL7303720 | 0.89 | KMT2A (0.50) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 | |
| Mandelic Acid SCHEMBL8716949 | 0.89 | KMT2A (0.50) | KMT2ACHEK1NAMPTPBKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476633-A | The inhibitor of tryptophan 2,3- dioxygenase | 荷兰转化研究中心有限责任公司 | 2019-03-15 | — | — | CN | disclosed |
| US-5763604-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5677448-A | CHEMICAL INTERMEDIATES FOR MAKING ANTAGONIST OF THROMBIN, TREATING THROMBOSIS, STROKE, INFLAMMATION, ARTERIOSCLEROSIS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5405854-A | Anticoagulants | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |
| CN-1076690-A | SULFONAMIDOCARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 1993-09-29 | — | — | CN | disclosed |