Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | ESR1 | P03372 | 5/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.67 |
| ▸ | ATM | Q13315 | 3/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.67 |
| ▸ | SHBG | P04278 | 1/20 | 0.67 |
| ▸ | FYN | P06241 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8723544 | 1.00 | KMT2A (0.67) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| Iodide SCHEMBL8727187 | 0.98 | MAPT (0.63) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| Iodide SCHEMBL9011178 | 0.98 | MAPT (0.63) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL3300046 | 0.91 | LMNA (0.80) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL3299315 | 0.86 | MAPT (0.81) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL8155723 | 0.86 | MAPT (0.81) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL3864661 | 0.85 | KMT2A (0.68) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL3870740 | 0.85 | KMT2A (0.68) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL3864673 | 0.85 | SMN1; SMN2 (0.67) | KMT2ALMNASMN1; SMN2ESR1ADORA3 | |
| SCHEMBL8722555 | 0.84 | KMT2A (0.69) | KMT2ALMNASMN1; SMN2ESR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335545-B2 | Pharmaceutical formulations for parenteral use | UNIV FLORIDA (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0327766-B1 | Redox systems for brain-targeted drug delivery | UNIV FLORIDA (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5024998-A | Administering in aqueous solution with cyclodextrin derivative | UNIVERSITY OF FLORIDA (US) | 1991-06-18 | — | — | US | disclosed |
| US-5017566-A | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | disclosed |
| US-5002935-A | Inclusion Complexing Hydroxypropylcyclodextrin with a Dihydropyridine-substituted Drug | UNIVERSITY OF FLORIDA (US) | 1991-03-26 | — | — | US | disclosed |
| US-4983586-A | Decreasing precipitation at injection site or in lungs or other organs by combining with hydroxypropyl-beta-cyclodextrin | UNIVERSITY OF FLORIDA (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0327766-A2 | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1989-08-16 | — | — | EP | disclosed |