SCHEMBL8724014

SCHEMBL8724014

CNC(=O)c1ccc(C=CC(=O)NCc2cccn2-c2ccc(Cl)c(CC(C)Oc3cccc4c(C)coc34)c2Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8724011 0.82 BDKRB2 (0.56) BDKRB2
SCHEMBL7010916 0.80 BDKRB2 (0.72) BDKRB2
SCHEMBL7010913 0.80 BDKRB2 (0.72) BDKRB2
SCHEMBL8724006 0.80 BDKRB2 (0.64) BDKRB2
SCHEMBL8724002 0.80 BDKRB2 (0.64) BDKRB2
SCHEMBL7007335 0.79 BDKRB2 (0.67) BDKRB2
SCHEMBL7012786 0.79 BDKRB2 (0.67) BDKRB2
SCHEMBL7007336 0.79 BDKRB2 (0.67) BDKRB2
SCHEMBL7012784 0.79 BDKRB2 (0.67) BDKRB2
SCHEMBL8595878 0.76 BDKRB2 (0.63) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861243-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-02 EP disclosed
WO-1997011069-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-27 WO disclosed