SCHEMBL872422

SCHEMBL872422

N=C(N)c1ccc(C[C@H](NC(=O)CNS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCCCC2)cc1

nearest known ligand 0.75

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PLG P00747 6/20 0.67
F10 P00742 5/20 0.67
PLAU P00749 2/20 0.67
F2 P00734 2/20 0.59
PRSS1 P07477 2/20 0.59
F12 P00748 1/20 0.55
KLKB1 P03952 1/20 0.55
PROC P04070 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29651383 1.00 PLG (0.67) PLGF10PLAUF2PRSS1
SCHEMBL8144360 1.00 PLG (0.67) PLGF10PLAUF2PRSS1
SCHEMBL29514928 1.00 PLG (0.67) PLGF10PLAUF2PRSS1
SCHEMBL9189122 1.00 PLG (0.67) PLGF10PLAUF2PRSS1
SCHEMBL7439785 0.89 PLG (0.83) PLGF10PLAUF12KLKB1
SCHEMBL3057528 0.86 F2 (0.60) PLGF10PLAUF2
SCHEMBL3419341 0.86 F2 (0.60) PLGF10PLAUF2
SCHEMBL4968238 0.85 PLG (0.62) PLGF10PLAUF2PRSS1
Piperidine SCHEMBL7370685 0.84 F2 (0.53) PLGF10PLAUF2PRSS1
SCHEMBL6787527 0.84 PLG (0.54) PLGF10PLAUF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376074-B1 METHOD FOR IMPROVED BIOACTIVATION OF MEDICATIONS DRITTE PATENTPORTFOLIO BETEILI (DE) 2019-03-13 EP disclosed
US-20120077876-A1 Method For Improved Bioactivation Of Pharmaceuticals DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG (DE) 2012-03-29 US disclosed
US-4791102-A ANTICOAGULANTS SANOFI (FR) 1988-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077876-A1 Method For Improved Bioactivation Of Pharmaceuticals CYP2B6, CYP1A2, CYP2D6 PLG 369/4885F10 1069/4885PLAU 1139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.