Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.53 |
| ▸ | F10 | P00742 | 5/20 | 0.52 |
| ▸ | PLAU | P00749 | 3/20 | 0.49 |
| ▸ | PLG | P00747 | 3/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PLAT | P00750 | 2/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419341 | 0.92 | F2 (0.60) | F2F10PLAUPLGTMPRSS6 | |
| SCHEMBL3057528 | 0.92 | F2 (0.60) | F2F10PLAUPLGTMPRSS6 | |
| SCHEMBL29514928 | 0.84 | PLG (0.67) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL29651383 | 0.84 | PLG (0.67) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL9189122 | 0.84 | PLG (0.67) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL872422 | 0.84 | PLG (0.67) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL8144360 | 0.84 | PLG (0.67) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL9664068 | 0.83 | F10 (0.71) | F2F10PLAUPLGTMPRSS6 | |
| SCHEMBL9710389 | 0.80 | F2 (0.70) | F2F10PLAUPLGTMPRSS6 | |
| SCHEMBL7370481 | 0.80 | F2 (0.58) | F2F10PLAUTMPRSS6PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250720-A | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5242904-A | Anticoagulant, antiinflammatory | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0293881-B1 | PEPTIDE BORONIC ACID INHIBITORS OF TRYPSIN-LIKE PROTEASES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5187157-A | Anticoagulant, antiinflammatory agents | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0293881-A2 | Peptide boronic acid inhibitors of trypsin-like proteases | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-12-07 | — | — | EP | disclosed |