Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | MIF | P14174 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276380 | 0.80 | KDM4E (0.72) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL8258964 | 0.80 | KDM4E (0.72) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL30682399 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL13790109 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL30912054 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL30912053 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL6286138 | 0.80 | MEN1 (0.60) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL6855264 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| SCHEMBL29769924 | 0.80 | SMN1; SMN2 (0.69) | KMT2AMEN1HCRTR1MIFMAPT | |
| Tryptophan Methyl Ester SCHEMBL475267 | 0.79 | MEN1 (0.70) | KMT2AMEN1HCRTR1MIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |