Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MIF | P14174 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13790109 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL30912053 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL29769924 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL30682399 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL30912054 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL6278978 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL9053137 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL6286138 | 0.86 | MEN1 (0.60) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL8258964 | 0.86 | KDM4E (0.72) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E | |
| SCHEMBL10276380 | 0.86 | KDM4E (0.72) | SMN1; SMN2MEN1KMT2AHCRTR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749635-B1 | PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF | HALDOR TOPSOE AS (DK) | 2022-07-13 | — | — | EP | disclosed |
| US-20210045414-A1 | PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF | HALDOR TOPSØE A/S (DK) | 2021-02-18 | — | — | US | disclosed |
| WO-2019154624-A1 | PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF | HALDOR TOPSØE A/S (DK) | 2019-08-15 | — | — | WO | disclosed |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-10-23 | — | — | US | disclosed |
| WO-2013019690-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | THE OHIO STATE UNIVERSITY (US) | 2013-02-07 | — | — | WO | disclosed |
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | disclosed |
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-20030187026-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-02 | — | — | US | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187026-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | SMN1; SMN2 2830/4885MEN1 1169/4885KMT2A 1640/4885 |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | IL6, STAT3, JAK2 | SMN1; SMN2 4654/4885MEN1 3590/4885KMT2A 2536/4885 |
| US-20030199511-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | SMN1; SMN2 2830/4885MEN1 1169/4885KMT2A 1640/4885 |
| US-20210045414-A1 | PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF | HAAO, CYP8B1, PAH | SMN1; SMN2 4057/4885MEN1 2912/4885KMT2A 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.