Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16686899 | 0.85 | NR4A2 (0.58) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL763777 | 0.82 | NR4A2 (0.56) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL16687075 | 0.81 | NR4A2 (0.55) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6617774 | 0.81 | NR4A2 (0.55) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL28709469 | 0.81 | NR4A2 (0.54) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14527164 | 0.81 | NR4A2 (0.51) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8726228 | 0.80 | HTR2A (0.60) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5646963 | 0.80 | HTR2A (0.59) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9936530 | 0.80 | NR4A2 (0.56) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 | |
| SCHEMBL28728192 | 0.80 | HTR1A (0.37) | NR4A2CREBBPKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |