Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.70 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.66 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.66 |
| ▸ | ITGAL | P20701 | 2/20 | 0.66 |
| ▸ | PLAU | P00749 | 1/20 | 0.63 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.63 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.62 |
| ▸ | ACE | P12821 | 2/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8724361 | 1.00 | TACR1 (0.70) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL16617905 | 0.90 | CTSL (0.67) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL16617908 | 0.90 | CTSL (0.67) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL21427023 | 0.90 | ITGB2 (0.70) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL23118282 | 0.89 | TACR1 (0.59) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL23118287 | 0.89 | EDNRB (0.60) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL29197301 | 0.89 | ITGB2 (0.66) | ITGB2ICAM1ITGALPLAUPLAUR | |
| SCHEMBL8721736 | 0.87 | EDNRB (0.77) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL23118288 | 0.87 | EDNRB (0.58) | TACR1ITGB2ICAM1ITGALPLAU | |
| SCHEMBL11227413 | 0.85 | CTSL (0.61) | TACR1ITGB2ICAM1ITGALPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |