Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7793839 | 0.73 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL7790730 | 0.72 | ALDH1A1 (0.39) | PARP1TP53TDP1ALDH1A1TSHR | |
| SCHEMBL12986970 | 0.68 | TP53 (0.41) | PARP1TP53TDP1ALDH1A1TSHR | |
| SCHEMBL29592963 | 0.68 | TP53 (0.41) | PARP1TP53TDP1ALDH1A1TSHR | |
| SCHEMBL3850055 | 0.65 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL2443320 | 0.64 | TYMS (0.42) | TP53TDP1ALDH1A1TSHR | |
| SCHEMBL16289143 | 0.64 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL29760312 | 0.64 | TYMS (0.42) | TP53TDP1ALDH1A1TSHR | |
| SCHEMBL3807899 | 0.63 | PPARG (0.44) | TDP1ALDH1A1TSHR | |
| SCHEMBL278142 | 0.62 | ALDH1A1 (0.45) | PARP1TP53TDP1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |