Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | F13A1 | P00488 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | TGM1 | P22735 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726088 | 0.84 | MAPT (0.63) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL6748039 | 0.82 | USP2 (0.76) | MAPTALDH1A1PKMUSP2NPC1 | |
| SCHEMBL6181332 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL16442322 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL29764424 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL1797016 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMTDO2PKLR | |
| SCHEMBL11510345 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL651924 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMPOLB | |
| SCHEMBL5955341 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMPOLB | |
| SCHEMBL9977868 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |