Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064054 | 0.78 | SRD5A1 (0.56) | ARSRD5A1SRD5A2 | |
| SCHEMBL8064052 | 0.78 | SRD5A1 (0.56) | ARSRD5A1SRD5A2 | |
| SCHEMBL8073934 | 0.74 | SRD5A1 (0.60) | SRD5A1SRD5A2 | |
| SCHEMBL8073932 | 0.74 | SRD5A1 (0.60) | SRD5A1SRD5A2 | |
| SCHEMBL9113667 | 0.73 | SRD5A1 (0.42) | ARSRD5A1MAPTSRD5A2 | |
| SCHEMBL8931601 | 0.70 | GPBAR1 (0.39) | CCR3SRD5A1SRD5A2 | |
| SCHEMBL8071797 | 0.68 | SRD5A1 (0.47) | SRD5A1SRD5A2 | |
| SCHEMBL8071800 | 0.68 | SRD5A1 (0.47) | SRD5A1SRD5A2 | |
| SCHEMBL9110856 | 0.67 | ALDH1A1 (0.36) | KMT2AMEN1ARSRD5A1MAPT | |
| SCHEMBL8074047 | 0.66 | SRD5A1 (0.56) | SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710275-A | ENZYME AND HORMONE INHIBITORS | MERCK & CO., INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | disclosed |