Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675533 | 0.92 | AKR1B1 (0.48) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL7682189 | 0.89 | PTGS2 (0.49) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| Methane SCHEMBL7674451 | 0.88 | PTGS2 (0.48) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL7685415 | 0.88 | PTGS2 (0.46) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| Ethane SCHEMBL7676908 | 0.86 | PTGS2 (0.47) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL7684729 | 0.83 | PTGS2 (0.47) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL7685429 | 0.83 | MAPK1 (0.49) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| Methane SCHEMBL7684820 | 0.82 | MAPK1 (0.48) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL11811275 | 0.79 | CNR2 (0.46) | PTGS2LMNATSHRHTTCNR2 | |
| SCHEMBL8458232 | 0.79 | PTGS1 (0.74) | PTGS1AKR1B1PTGS2CXCL8GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |