Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.63 |
| ▸ | HMGCR | P04035 | 5/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL874066 | 0.98 | PTPN7 (0.67) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL19260208 | 0.93 | PTPN7 (0.54) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967833 | 0.93 | PTPN7 (0.71) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967903 | 0.90 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967786 | 0.90 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967688 | 0.90 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL55966 | 0.87 | — | — | |
| SCHEMBL9015846 | 0.85 | PTPN7 (0.54) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL161365 | 0.85 | PTPN7 (0.54) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL4224620 | 0.85 | PTPN7 (0.54) | PTPN7HMGCRRECQLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9358191-B2 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2016-06-07 | — | — | US | disclosed |
| US-20140271522-A1 | DEODORANT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-09-18 | — | — | US | disclosed |
| US-8778320-B2 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-07-15 | — | — | US | disclosed |
| EP-1561476-B1 | DEODORANT COMPOSITION | TAKASAGO PERFUMERY CO LTD (JP) | 2014-02-12 | — | — | EP | disclosed |
| EP-2618856-A1 | DEODORANT COMPOSITION FOR SULFIDES | Takasago International Corporation (JP) | 2013-07-31 | — | — | EP | disclosed |
| US-20130136713-A1 | DEODORANT COMPOSITION FOR SULFIDES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-05-30 | — | — | US | disclosed |
| WO-2012039516-A1 | DEODORANT COMPOSITION FOR SULFIDES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-03-29 | — | — | WO | disclosed |
| US-20090087401-A1 | DEODORANT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2009-04-02 | — | — | US | disclosed |
| US-20060165622-A1 | Deodorant composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1561476-A1 | DEODORANT COMPOSITION | Takasago International Corporation (JP) | 2005-08-10 | — | — | EP | disclosed |