Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.75 |
| ▸ | HMGCR | P04035 | 3/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARD | Q03181 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL15967903 | 1.00 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967688 | 1.00 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967833 | 0.97 | PTPN7 (0.71) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL874066 | 0.93 | PTPN7 (0.67) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL872743 | 0.90 | PTPN7 (0.63) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967929 | 0.89 | PTPN7 (0.60) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL30656137 | 0.88 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL874695 | 0.88 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| SCHEMBL24469785 | 0.86 | PTPN7 (1.00) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| SCHEMBL11203210 | 0.86 | PTPN7 (0.92) | PTPN7HMGCRTDP1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2779299-B1 | NONAQUEOUS ELECTROLYTE SOLUTION, AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY USING SAID ELECTROLYTE SOLUTION | ADEKA CORP (JP) | 2017-08-02 | — | — | EP | disclosed |
| US-9419306-B2 | Nonaqueous electrolyte and nonaqueous secondary battery using same | ADEKA CORPORATION (JP) | 2016-08-16 | — | — | US | disclosed |
| EP-2775559-B1 | NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY | ADEKA CORP (JP) | 2016-07-06 | — | — | EP | disclosed |
| US-9337511-B2 | Nonaqueous secondary battery | ADEKA CORPORATION (JP) | 2016-05-10 | — | — | US | disclosed |
| US-20150044551-A1 | NONAQUEOUS SECONDARY BATTERY | ADEKA CORPORATION (JP) | 2015-02-12 | — | — | US | disclosed |
| EP-2779299-A1 | NONAQUEOUS ELECTROLYTE SOLUTION, AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY USING SAID ELECTROLYTE SOLUTION | Adeka Corporation (JP) | 2014-09-17 | — | — | EP | disclosed |
| EP-2775559-A1 | NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY | Adeka Corporation (JP) | 2014-09-10 | — | — | EP | disclosed |
| US-20140242456-A1 | NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY USING SAME | ADEKA CORPORATION (JP) | 2014-08-28 | — | — | US | disclosed |