Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10458795 | 0.72 | ESR1 (0.44) | ESR1ESR2CYP3A4ALDH1A1BLM | |
| SCHEMBL9644070 | 0.71 | ESR1 (0.50) | ESR1ESR2CYP3A4ALDH1A1CPT1B | |
| SCHEMBL8727572 | 0.69 | ESR1 (0.47) | ESR1ESR2CYP3A4ALDH1A1BLM | |
| SCHEMBL8028384 | 0.69 | ESR1 (0.48) | ESR1ESR2CYP3A4ALDH1A1BLM | |
| SCHEMBL4206889 | 0.69 | CA2 (0.48) | ESR1ESR2CYP3A4ALDH1A1CPT1B | |
| SCHEMBL31647379 | 0.68 | BLM (0.42) | ESR1ESR2CYP3A4ALDH1A1CPT1B | |
| SCHEMBL4220470 | 0.67 | ESR1 (0.44) | ESR1ESR2CYP3A4ALDH1A1CPT1B | |
| SCHEMBL9153305 | 0.67 | ESR1 (0.44) | ESR1ESR2CYP3A4ALDH1A1CPT1B | |
| SCHEMBL24288076 | 0.66 | ESR1 (0.54) | ESR1ESR2CYP3A4ALDH1A1TYR | |
| SCHEMBL9792726 | 0.66 | CYP1A2 (0.43) | ESR1ESR2CYP3A4ALDH1A1CPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831769-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040048-A9 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | — | 1997-03-27 | — | — | WO | claimed |
| WO-1996040048-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1996-12-19 | — | — | WO | claimed |