SCHEMBL8728688

SCHEMBL8728688

CC(Cc1ccccc1)C(=O)c1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 1/20 0.66
HPGD P15428 1/20 0.54
CYP3A4 P08684 3/20 0.53
KMT2A Q03164 3/20 0.53
TSHR P16473 1/20 0.53
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
MAPK1 P28482 1/20 0.51
HSD17B10 Q99714 2/20 0.50
SIGMAR1 Q99720 1/20 0.50
PGR P06401 1/20 0.50
ADRA2A P08913 1/20 0.50
ADRA2B P18089 1/20 0.50
HTR2A P28223 1/20 0.50
HRH1 P35367 1/20 0.50
KCNH2 Q12809 1/20 0.50
CYP1A2 P05177 1/20 0.50
ALDH1A1 P00352 3/20 0.49
MAPT P10636 2/20 0.49
MEN1 O00255 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8728691 1.00 MDM2 (0.66) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL21969032 0.91 MDM2 (0.55) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL31561605 0.89 MDM2 (0.53) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL31561601 0.89 MDM2 (0.53) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL31561615 0.88 MDM2 (0.51) MDM2HPGDCYP3A4RAB9APGR
SCHEMBL11307784 0.88 MDM2 (0.51) MDM2KMT2AMAPTMEN1L3MBTL1
SCHEMBL31561617 0.88 KMT2A (0.57) MDM2HPGDKMT2ANPC1RAB9A
SCHEMBL9665304 0.88 RAB9A (0.56) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL31561600 0.88 KMT2A (0.61) MDM2HPGDCYP3A4KMT2ATSHR
SCHEMBL31561612 0.85 PPARG (0.57) MDM2KMT2ANPC1RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115011576-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS5, and coding gene and application thereof 中国医学科学院药用植物研究所 2022-09-06 CN claimed
CN-114990084-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS4, and coding gene and application thereof 中国医学科学院药用植物研究所 2022-09-02 CN claimed
CN-107857697-B Synthesis method of 2-methyl-1, 3-diphenylpropan-1-one 郑州大学 2020-07-31 CN claimed
CN-119798058-A Preparation method of alpha-alkyl ketone derivative 浙江工业大学 2025-04-11 CN disclosed
CN-115161300-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS3 and coding gene and application thereof 中国医学科学院药用植物研究所 2022-10-11 CN disclosed
CN-115161300-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS3 and coding gene and application thereof 中国医学科学院药用植物研究所 2022-10-11 CN disclosed
CN-115011576-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS5, and coding gene and application thereof 中国医学科学院药用植物研究所 2022-09-06 CN disclosed
CN-114990084-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS4, and coding gene and application thereof 中国医学科学院药用植物研究所 2022-09-02 CN disclosed
CN-114990084-A Aquilaria sinensis-derived III-type polyketide synthase AsPKS4, and coding gene and application thereof 中国医学科学院药用植物研究所 2022-09-02 CN disclosed
CN-107857697-B Synthesis method of 2-methyl-1, 3-diphenylpropan-1-one 郑州大学 2020-07-31 CN disclosed
CN-107857697-B Synthesis method of 2-methyl-1, 3-diphenylpropan-1-one 郑州大学 2020-07-31 CN disclosed
CN-107857697-B Synthesis method of 2-methyl-1, 3-diphenylpropan-1-one 郑州大学 2020-07-31 CN disclosed
CN-105439787-B Method for synthesizing α -alkyl ketone 南京理工大学 2018-02-13 CN disclosed
CN-105439787-A Method for synthesizing alpha-alkyl ketone UNIV NANJING SCIENCE & TECH 2016-03-30 CN disclosed
EP-0751927-A4 SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY CALIFORNIA INST OF TECHN (US) 1998-07-29 EP disclosed
EP-0751927-A1 SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1997-01-08 EP disclosed
US-5488131-A Synthesis of compounds with predetermined chirality CALIFORNIA INSTITUTE OF TECHNOLOGY 1996-01-30 US disclosed
WO-1995025714-A1 SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1995-09-28 WO disclosed