Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30297390 | 0.84 | TSHR (0.48) | TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL5520472 | 0.84 | TSHR (0.48) | TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL5520469 | 0.84 | TSHR (0.48) | TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL10170027 | 0.84 | TSHR (0.48) | TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL5873976 | 0.83 | FAAH (0.46) | LPAR3LPAR1LPAR2 | |
| SCHEMBL5873974 | 0.83 | FAAH (0.46) | LPAR3LPAR1LPAR2 | |
| SCHEMBL9869504 | 0.81 | FAAH (0.50) | LPAR3LPAR1LPAR2 | |
| SCHEMBL10817849 | 0.81 | TSHR (0.38) | TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL9869502 | 0.81 | FAAH (0.50) | LPAR3LPAR1LPAR2 | |
| SCHEMBL8728592 | 0.80 | PTGS1 (0.32) | LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |