Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453073 | 0.94 | TSHR (0.52) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL6824408 | 0.85 | TSHR (0.55) | TSHRCETPSMN1; SMN2 | |
| SCHEMBL7434180 | 0.84 | TSHR (0.61) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL4414066 | 0.79 | S1PR2 (0.72) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL8729222 | 0.78 | S1PR2 (0.70) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| Zinc Ion SCHEMBL28530931 | 0.78 | TSHR (0.53) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL28541500 | 0.78 | TSHR (0.53) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL3208019 | 0.78 | S1PR2 (0.75) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL8949998 | 0.78 | S1PR2 (0.75) | TSHRS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL2399825 | 0.78 | S1PR2 (0.75) | TSHRS1PR2S1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701561-B1 | DESOXYAZAPHOSPHOLIPID DERIVATIVES HAVING INHIBITING ACTIVITY ON PHOSPHOLIPASE A2 | MENARINI LAB (ES) | 1998-08-19 | — | — | EP | disclosed |
| EP-0701561-A1 | DESOXYAZAPHOSPHOLIPID DERIVATIVES HAVING INHIBITING ACTIVITY ON PHOSPHOLIPASE A2 | LABORATORIOS MENARINI S.A. (ES) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994028004-A1 | DESOXYAZAPHOSPHOLIPID DERIVATIVES HAVING INHIBITING ACTIVITY ON PHOSPHOLIPASE A2 | LABORATORIOS MENARINI S.A. (ES) | 1994-12-08 | — | — | WO | disclosed |
| US-4900860-A | Process for preparing phosphonyloxyacyl amino acids | E. R. SQUIBB & SONS, INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4885380-A | REACTING PHOSPHONIC ACID DICHLORIDE WITH ALPHA-HYDROXY ACID TO FORM CYCLIC MIXED ANHYDRIDE; REACTING WITH AMINO ACID | THOTTATHIL JOHN K (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0237264-A2 | Process for preparing phosphonyloxyacyl amino acids and derivates thereof | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |