Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8730265 | 0.87 | SMN1; SMN2 (0.71) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL12189230 | 0.85 | SMN1; SMN2 (0.78) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL8728928 | 0.84 | ATM (0.69) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL25081110 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL568444 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL19602434 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL6882566 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL12315302 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2USP2ATMPOLBTSHR | |
| SCHEMBL8724926 | 0.80 | POLB (0.67) | SMN1; SMN2POLBTSHRKMT2AMEN1 | |
| SCHEMBL8726088 | 0.80 | MAPT (0.63) | SMN1; SMN2USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |