SCHEMBL8729273

SCHEMBL8729273

C=CC(=O)OCCCOc1ccc(-c2ccc(COc3ccccc3C#N)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.46
FFAR1 O14842 4/20 0.45
AKR1B1 P15121 1/20 0.45
XDH P47989 4/20 0.41
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MMP3 P08254 1/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38
PTPN1 P18031 1/20 0.37
PPARG P37231 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
MMP2 P08253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8723299 0.98 THRB (0.46) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8728094 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8728244 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8725675 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8724440 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8727990 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8727988 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8728340 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8724328 0.97 THRB (0.45) THRBFFAR1AKR1B1XDHNPC1
SCHEMBL8723330 0.87 THRB (0.45) THRBFFAR1AKR1B1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5800733-A Photo cross-linkable liquid crystal derivatives ROLIC AG (CH) 1998-09-01 US disclosed