SCHEMBL8730266

SCHEMBL8730266

CN(C)c1ccccc1CCl.[Ti]C1=CC=CC1

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
GLI1 P08151 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
ATP4A P20648 1/20 0.32
ATP4B P51164 1/20 0.32
AR P10275 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8734874 0.85 SLC6A4 (0.36) ALDH1A1GLI1CYP3A4CYP2D6
SCHEMBL8677875 0.82 ALDH1A1 (0.32) ALDH1A1GLI1CYP3A4CYP2D6AR
SCHEMBL1847274 0.80 ALDH1A1 (0.40) ALDH1A1GLI1CYP3A4CYP2D6ATP4A
SCHEMBL8849879 0.80 ALDH1A1 (0.40) ALDH1A1GLI1CYP3A4CYP2D6ATP4A
Hydrochloric Acid SCHEMBL9266349 0.78 AR (0.39) ALDH1A1GLI1CYP3A4CYP2D6ATP4A
SCHEMBL6906463 0.78 AR (0.39) ALDH1A1GLI1CYP3A4CYP2D6ATP4A
Hydrochloric Acid SCHEMBL8657787 0.78 AR (0.39) ALDH1A1GLI1CYP3A4CYP2D6ATP4A
Methylene Chloride SCHEMBL5909780 0.72
Ethyl Chloride SCHEMBL9193219 0.70
Ethyl Chloride SCHEMBL27341108 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0632819-B1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES DOW CHEMICAL CO (US) 1998-09-02 EP disclosed
US-5532394-A CONTAINING TITANIUM, DIVALENT MOIETY, LINKING GROUP, MONOVALENT ANIONIC STABILIZING GROUP THE DOW CHEMICAL COMPANY (US) 1996-07-02 US disclosed
EP-0632819-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1995-01-11 EP disclosed
WO-1993019104-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1993-09-30 WO disclosed