SCHEMBL8730466

SCHEMBL8730466

C=C[C@H]1CC[C@H](c2ccc(-c3ccc(-c4ccc(COC)cc4)cc3)c(F)c2)CC1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.35
CYP2C9 P11712 2/20 0.35
APP P05067 2/20 0.35
FASN P49327 1/20 0.34
FFAR4 Q5NUL3 2/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
ABCB1 P08183 2/20 0.32
ERN1 O75460 1/20 0.31
F10 P00742 1/20 0.31
HTR2A P28223 1/20 0.31
GRM2 Q14416 1/20 0.31
CHKA P35790 1/20 0.31
NAAA Q02083 1/20 0.30
ALOX5 P09917 1/20 0.30
GABRA1 P14867 1/20 0.30
CNR2 P34972 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8725252 0.94 CYP3A4 (0.36) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8728184 0.94 CYP3A4 (0.36) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8731133 0.93 L3MBTL1 (0.38) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8732323 0.87 FASN (0.34) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8732273 0.86 CYP3A4 (0.35) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8732266 0.86 CYP3A4 (0.35) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8732270 0.86 CYP3A4 (0.35) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8732276 0.86 CYP3A4 (0.35) CYP3A4CYP2C9APPFASNFFAR4
SCHEMBL8725395 0.86 L3MBTL1 (0.36) CYP3A4CYP2C9APPFFAR4CYP2D6
SCHEMBL8732242 0.85 F10 (0.34) FFAR4L3MBTL1ABCB1F10HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882695-A1 BENZYL ETHER DERIVATIVES, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY CHISSO CORPORATION (JP) 1998-12-09 EP disclosed