Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87301 | 0.89 | MAPT (0.40) | MAPTALDH1A1TSHRRAB9AALOX15 | |
| SCHEMBL87323 | 0.84 | F2 (0.43) | MAPTALDH1A1TSHRRAB9AALOX15 | |
| SCHEMBL13691707 | 0.82 | KCNH2 (0.46) | MAPTTSHRSMN1; SMN2NPSR1GAA | |
| SCHEMBL87444 | 0.80 | MAPT (0.48) | MAPTALDH1A1TSHRRAB9AALOX15 | |
| SCHEMBL87293 | 0.71 | TSHR (0.33) | MAPTALDH1A1TSHRRAB9AALOX15 | |
| SCHEMBL2530132 | 0.69 | MAPT (0.45) | MAPTALDH1A1TSHRRAB9AALOX15 | |
| SCHEMBL87285 | 0.69 | CYP1A2 (0.40) | MAPTALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL16145641 | 0.69 | ACHE (0.53) | — | |
| SCHEMBL87894 | 0.68 | TSHR (0.34) | TSHRRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL13691809 | 0.67 | KCNH2 (0.45) | MAPTALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| WO-2009117540-A1 | BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-24 | — | — | WO | disclosed |