Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873244 | 1.00 | HDAC6 (0.68) | HDAC6HDAC1HDAC8OPRK1ALDH1A1 | |
| SCHEMBL8452072 | 0.92 | HDAC6 (0.73) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL877776 | 0.92 | HDAC6 (0.73) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL876552 | 0.92 | HDAC6 (0.73) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL5365461 | 0.88 | HDAC6 (0.69) | HDAC6HDAC1HDAC8OPRK1ALDH1A1 | |
| SCHEMBL877786 | 0.88 | HDAC6 (0.69) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL4289428 | 0.88 | HDAC6 (0.69) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL16457753 | 0.88 | HDAC6 (0.69) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL2084503 | 0.88 | OPRK1 (0.63) | HDAC6HDAC1HDAC8OPRK1ALDH1A1 | |
| SCHEMBL3494772 | 0.87 | HDAC6 (0.71) | HDAC6HDAC1HDAC8OPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |