Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.66 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.64 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.64 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512475 | 0.91 | PDE10A (0.77) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL27485722 | 0.90 | CYSLTR1 (0.75) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10547475 | 0.88 | CYSLTR1 (0.76) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8736559 | 0.87 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8734106 | 0.86 | PDE10A (0.66) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8179931 | 0.84 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10547704 | 0.84 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8736552 | 0.84 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL13772898 | 0.84 | CYSLTR1 (0.69) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10547803 | 0.83 | CYSLTR1 (0.69) | PDE10ACYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4661596-A | Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-04-28 | — | — | US | claimed |
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |
| US-4754043-A | LIPOXYGENASE INHIBITORS, ASTHMA, RHINITIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-28 | — | — | US | disclosed |
| US-4719308-A | ANTIINFLAMMATORY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4661596-A | Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-04-28 | — | — | US | disclosed |