Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.64 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.62 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512475 | 0.90 | PDE10A (0.77) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL8732702 | 0.87 | PDE10A (0.66) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10545363 | 0.86 | CYSLTR1 (0.71) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL8734106 | 0.84 | PDE10A (0.66) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8179931 | 0.83 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8736552 | 0.83 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL10846145 | 0.83 | PDE10A (0.68) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL26774846 | 0.83 | CYSLTR1 (0.69) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8735648 | 0.81 | CYSLTR1 (0.78) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL7801642 | 0.80 | GPBAR1 (0.81) | CYSLTR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |