SCHEMBL8732971

SCHEMBL8732971

CC1=C(C)C(C)(C)C([Ti](Cc2ccccc2N(C)C)C2=C(C)C(C)=C(C)C2(C)C)=C1C

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
GLI1 P08151 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CHEK1 O14757 1/20 0.30
NEK2 P51955 1/20 0.30
LIMK1 P53667 1/20 0.30
DYRK1A Q13627 1/20 0.30
CLK4 Q9HAZ1 1/20 0.30
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8732979 0.70 SLC6A4 (0.34) ALDH1A1GLI1CYP3A4CYP2D6
SCHEMBL9069877 0.70 ALDH1A1 (0.30) ALDH1A1GLI1CYP3A4CYP2D6
SCHEMBL8734858 0.70 ALDH1A1 (0.30) ALDH1A1GLI1CYP3A4CYP2D6
SCHEMBL7171055 0.65 ELANE (0.33) ALDH1A1CYP3A4
SCHEMBL8676004 0.65 ALDH1A1 (0.33) ALDH1A1GLI1CYP3A4CYP2D6AR
SCHEMBL2231713 0.64 MAPT (0.40) ALDH1A1GLI1CYP3A4CYP2D6CHEK1
SCHEMBL3871304 0.63 AR (0.50) ALDH1A1GLI1CYP3A4CYP2D6CHEK1
SCHEMBL29408555 0.63 AR (0.50) ALDH1A1GLI1CYP3A4CYP2D6CHEK1
SCHEMBL906361 0.62
SCHEMBL6907203 0.62 AR (0.39) ALDH1A1GLI1CYP3A4CYP2D6CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0632819-B1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES DOW CHEMICAL CO (US) 1998-09-02 EP disclosed
US-5532394-A CONTAINING TITANIUM, DIVALENT MOIETY, LINKING GROUP, MONOVALENT ANIONIC STABILIZING GROUP THE DOW CHEMICAL COMPANY (US) 1996-07-02 US disclosed
EP-0632819-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1995-01-11 EP disclosed
WO-1993019104-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1993-09-30 WO disclosed