Acetic Acid

Acetic Acid

SCHEMBL8733648

CC(=O)O.COc1ccc2[nH]c(C)c(Cc3ccc(Cl)cc3)c2c1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 1/20 0.68
AKR1C2 P52895 1/20 0.62
MTNR1A P48039 5/20 0.57
MTNR1B P49286 5/20 0.57
HTR1D P28221 2/20 0.52
HTR6 P50406 2/20 0.52
PTGS1 P23219 2/20 0.51
PTGS2 P35354 2/20 0.51
PPARG P37231 2/20 0.51
HDAC1 Q13547 1/20 0.51
HTR1A P08908 1/20 0.50
SLC6A2 P23975 1/20 0.50
HTR1E P28566 1/20 0.50
HTR7 P34969 1/20 0.50
HTR5A P47898 1/20 0.50
NQO2 P16083 1/20 0.50
TBXAS1 P24557 1/20 0.49
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7696761 0.81 AKR1C2 (0.61) PTPN5AKR1C2MTNR1AMTNR1BPTGS1
Deschlorobenzoyl Indomethacin SCHEMBL454792 0.77 AKR1C2 (1.00) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
SCHEMBL10205891 0.77 AKR1C2 (0.80) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
SCHEMBL6989119 0.77 PTGS1 (0.58) PTPN5HTR6PTGS1PTGS2HTR7
SCHEMBL9359811 0.76 AKR1C2 (0.62) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
Hydrochloric Acid SCHEMBL25260391 0.76 AKR1C2 (0.61) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
SCHEMBL11793036 0.76 AKR1C2 (0.61) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
SCHEMBL3264594 0.76 MTNR1A (0.71) AKR1C2MTNR1AMTNR1BPTGS2NQO2
SCHEMBL852717 0.75 AKR1C2 (0.76) PTPN5AKR1C2MTNR1AMTNR1BHTR1D
SCHEMBL11791916 0.75 AKR1C2 (0.60) PTPN5AKR1C2MTNR1AMTNR1BHTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805684-A4 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN UNIV TEXAS (US) 1998-08-05 EP disclosed
EP-0805684-A2 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1997-11-12 EP disclosed
WO-1996022780-A1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-08-01 WO disclosed