SCHEMBL8733677

SCHEMBL8733677

C=C/C(C)=C/C[C@@H]1[C@@]2(C)CCCC(C)(CO)[C@@H]2CC[C@@]1(C)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
POLB P06746 1/20 0.44
ALDH1A1 P00352 3/20 0.43
CYP3A4 P08684 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
HSD11B1 P28845 2/20 0.42
HSD11B2 P80365 1/20 0.41
CDC25A P30304 3/20 0.41
CDC25B P30305 3/20 0.41
LMNA P02545 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NR1H3 Q13133 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
BCHE P06276 3/20 0.34
ACHE P22303 2/20 0.34
TTL Q8NG68 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8733674 1.00 MAPT (0.44) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL541382 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL25669585 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL8731628 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL15220009 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL18089046 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL9549996 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL9550004 0.86 ALDH1A1 (0.57) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL8734680 0.79 MAPT (0.34) MAPTPOLBALDH1A1CYP3A4MEN1
SCHEMBL8734676 0.79 MAPT (0.34) MAPTPOLBALDH1A1CYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5773005-A ENZYME INHIBITORS, ANTISECRETORY AGENTS AND ANTIANDROGENS KABUSHIKI KAISHA YAKURIGAKU CHUO KENKYUSHO (JP) 1998-06-30 US claimed
US-5773005-A ENZYME INHIBITORS, ANTISECRETORY AGENTS AND ANTIANDROGENS KABUSHIKI KAISHA YAKURIGAKU CHUO KENKYUSHO (JP) 1998-06-30 US disclosed
EP-0747048-A2 Diterpenes and flavonoids as 5-alpha-reductase inhibitors Kabushiki Kaisha Yakurigaku Chuo Kenkyusho (JP) 1996-12-11 EP disclosed