Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MARS1 | P56192 | 9/20 | 0.42 |
| ▸ | GCG | P01275 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733799 | 0.86 | PTGS2 (0.70) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL2239972 | 0.85 | PTGS2 (0.76) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8732399 | 0.83 | PTGS2 (0.65) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8728786 | 0.81 | PTGS2 (0.60) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7680829 | 0.80 | SMN1; SMN2 (0.53) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8458232 | 0.79 | PTGS1 (0.74) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7685392 | 0.78 | PTGS2 (0.60) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8729441 | 0.77 | PTGS2 (0.91) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8729555 | 0.77 | PTGS2 (0.72) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8732168 | 0.77 | PTGS2 (0.67) | PTGS2CXCL8AKR1B1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |