SCHEMBL8733901

SCHEMBL8733901

Oc1c(F)c(-c2c(F)c(O)c(C(F)(F)F)c(F)c2F)c(F)c(F)c1C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20548535 0.83 SMN1; SMN2 (0.34) TSHRSMN1; SMN2
SCHEMBL24254677 0.80 SMN1; SMN2 (0.38) TSHRSMN1; SMN2
SCHEMBL28505018 0.80 SMN1; SMN2 (0.38) TSHRSMN1; SMN2
SCHEMBL14062566 0.78 TSHR (0.30) TSHRSMN1; SMN2
SCHEMBL14062570 0.78 TSHR (0.30) TSHRSMN1; SMN2
SCHEMBL25641524 0.77 SMN1; SMN2 (0.37) TSHRSMN1; SMN2
SCHEMBL25640950 0.77 SMN1; SMN2 (0.37) TSHRSMN1; SMN2
SCHEMBL14062571 0.77
SCHEMBL6440511 0.75 TSHR (0.31) TSHRSMN1; SMN2
SCHEMBL186352 0.75 SMN1; SMN2 (0.40) TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824096-A2 Process for the preparation of halogenated (meth)acrylic esters and poly (meth) arcylates obtained with said (meth)acrylic esters Akzo Nobel N.V. (NL) 1998-02-18 EP disclosed