Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tolbutamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | LMNA | P02545 | 3/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | ALB | P02768 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | FBP1 | P09467 | 7/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolbutamide SCHEMBL15918 | 0.97 | ALDH1A1 (1.00) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL1536920 | 0.97 | ALDH1A1 (1.00) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL28046582 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL7551276 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL11356450 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL4367531 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL28184306 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL11357518 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL140363 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB | |
| Tolbutamide SCHEMBL668223 | 0.96 | ALDH1A1 (0.97) | ALDH1A1LMNACYP2C9TSHRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117903018-A | Preparation method of tolbutamide crystal | 内蒙古科技大学 | 2024-04-19 | — | — | CN | claimed |
| CN-117903018-A | Preparation method of tolbutamide crystal | 内蒙古科技大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-117903018-A | Preparation method of tolbutamide crystal | 内蒙古科技大学 | 2024-04-19 | — | — | CN | disclosed |
| EP-0797442-A4 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE & EAR INFIRM (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0797442-A1 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996000073-A1 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 1996-01-04 | — | — | WO | disclosed |