Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 10/20 | 0.55 |
| ▸ | ESR1 | P03372 | 7/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594294 | 0.88 | ESR2 (0.52) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL3636461 | 0.84 | ESR1 (0.50) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL9396526 | 0.83 | CYP1A2 (0.44) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL8735778 | 0.75 | ESR2 (0.53) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL27822806 | 0.72 | CYP2A6 (0.39) | CYP1A2 | |
| SCHEMBL2124794 | 0.71 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL5030675 | 0.71 | CYP1A2 (0.44) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL8777379 | 0.71 | CYP1A2 (0.44) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL3927261 | 0.70 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL29093556 | 0.69 | ESR1 (0.46) | HSD17B1HSD17B2ESR1ESR2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826680-A1 | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |