Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594294 | 0.89 | ESR2 (0.52) | ESR1ESR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9396526 | 0.88 | CYP1A2 (0.44) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL8734007 | 0.84 | HSD17B1 (0.55) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL9418157 | 0.81 | ESR1 (0.47) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL8777379 | 0.75 | CYP1A2 (0.44) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL5030675 | 0.75 | CYP1A2 (0.44) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL8735778 | 0.75 | ESR2 (0.53) | ESR1ESR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5591900 | 0.73 | KIF11 (0.50) | ESR1ESR2 | |
| SCHEMBL27096453 | 0.72 | ESR1 (0.44) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL7735652 | 0.69 | HSD17B1 (0.49) | CYP1A2CYP3A4CYP2C9HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346014-B1 | Therapeutic product for the treatment of peri- or postmenopausal conditions | ZENECA LTD (GB) | 1994-08-03 | — | — | EP | claimed |
| US-5183814-A | Administering estrogen and antiestrogen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-02 | — | — | US | claimed |
| EP-0166509-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-13 | — | — | EP | claimed |
| US-4904661-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-27 | — | — | US | claimed |
| EP-0160508-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | claimed |
| US-4833135-A | Antioestrogenic phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-23 | — | — | US | claimed |
| US-4760061-A | Antioestrogenic agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-07-26 | — | — | US | claimed |
| US-4732912-A | ANTIESTROGENS, ANTITUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-22 | — | — | US | claimed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | claimed |
| EP-0166509-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-02 | — | — | EP | claimed |
| EP-0160508-A2 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-11-06 | — | — | EP | claimed |
| EP-0124369-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-11-07 | — | — | EP | claimed |
| EP-2155769-A2 | TISSUE DEGENERATION PROTECTION | Katholieke Universiteit Leuven (BE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008134828-A2 | TISSUE DEGENERATION PROTECTION | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2008-11-13 | — | — | WO | disclosed |
| EP-1140192-B1 | USE OF THE CYCLOOXYGENASE-2 INHIBITOR CELECOXIB AND CAPECITABINE FOR COMBINATION THERAPY IN NEOPLASIA | SEARLE LLC (US) | 2006-04-05 | — | — | EP | disclosed |
| CN-1164188-A | Naphthyl compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 1997-11-05 | — | — | CN | disclosed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | disclosed |
| EP-0166509-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-02 | — | — | EP | disclosed |
| EP-0160508-A2 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-11-06 | — | — | EP | disclosed |
| EP-0124369-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-11-07 | — | — | EP | disclosed |