SCHEMBL8734574

SCHEMBL8734574

CC1(C)c2ccccc2-c2ccc(-c3cc(-c4ccccc4)nc(-c4ccc(-n5c6ccc(F)cc6c6cc(F)ccc65)cc4)n3)cc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 1/20 0.36
▸ JAK3 P52333 1/20 0.36
▸ DHODH Q02127 1/20 0.35
▸ MAPT P10636 7/20 0.34
▸ MEN1 O00255 6/20 0.34
▸ KMT2A Q03164 6/20 0.34
▸ ALDH1A1 P00352 4/20 0.34
▸ HPGD P15428 4/20 0.34
▸ NTSR1 P30989 1/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ PGR P06401 3/20 0.34
▸ LMNA P02545 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ GLA P06280 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ NR3C1 P04150 2/20 0.33
▸ PDK2 Q15119 2/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8735460 0.89 KMT2A (0.38) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL8735792 0.89 KMT2A (0.38) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL6375108 0.88 KDM4E (0.36) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL8735731 0.88 MEN1 (0.37) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL8736945 0.88 MEN1 (0.37) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL8735330 0.88 MEN1 (0.37) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL8734507 0.88 MEN1 (0.37) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL6373277 0.87 KDM4E (0.35) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL19061343 0.87 MEN1 (0.35) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL19061845 0.87 MEN1 (0.35) MAPTMEN1KMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9266851-B2 Fluorene-containing aromatic compound, material for organic electroluminescent element, and organic electroluminescent element using same IDEMITSU KOSAN CO., LTD. (JP) 2016-02-23 — — US disclosed
US-9266851-B2 Fluorene-containing aromatic compound, material for organic electroluminescent element, and organic electroluminescent element using same IDEMITSU KOSAN CO., LTD. (JP) 2016-02-23 — — US disclosed
US-20120126217-A1 FLUORENE-CONTAINING AROMATIC COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME IDEMITSU KOSAN CO. LTD. (JP) 2012-05-24 — — US disclosed
US-20120126217-A1 FLUORENE-CONTAINING AROMATIC COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME IDEMITSU KOSAN CO. LTD. (JP) 2012-05-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120126217-A1 FLUORENE-CONTAINING AROMATIC COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME NR0B2, AFF2, AFF1 JAK2 937/4885JAK3 1419/4885DHODH 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback