Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 5/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29492858 | 0.90 | ADRB2 (0.68) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL2844967 | 0.90 | ADRB2 (0.68) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL143605 | 0.88 | ADRB2 (0.64) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL8927420 | 0.88 | ADRB2 (0.51) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL115991 | 0.87 | ADRB2 (0.62) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL7810922 | 0.87 | ADRB2 (0.58) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL7575069 | 0.86 | ADRB2 (0.61) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL9188190 | 0.86 | ADRB2 (0.61) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL10627001 | 0.86 | ADRB2 (0.66) | ADRB2STAT3TOP2ATOP2BKCNH2 | |
| SCHEMBL1989474 | 0.85 | ADRB2 (0.61) | ADRB2STAT3TOP2ATOP2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878194-A1 | REMEDIES OR PREVENTIVES FOR AIDS | SANKYO COMPANY LIMITED (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0304087-B1 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER LAMBERT CO (US) | 1994-03-30 | — | — | EP | disclosed |
| US-4933335-A | Quinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1990-06-12 | — | — | US | disclosed |
| US-4851418-A | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0304087-A2 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-02-22 | — | — | EP | disclosed |
| EP-0302525-A2 | Quinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-02-08 | — | — | EP | disclosed |
| US-4803205-A | Quinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| US-4780468-A | 8-trifluoromethyl quinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1988-10-25 | — | — | US | disclosed |