SCHEMBL8735640

SCHEMBL8735640

CCP(=O)(COS(=O)(=O)c1cc(F)ccc1F)OC(C)C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.34
KDM4E B2RXH2 1/20 0.34
PSEN1 P49768 5/20 0.33
PSEN2 P49810 5/20 0.33
APH1B Q8WW43 5/20 0.33
NCSTN Q92542 5/20 0.33
APH1A Q96BI3 5/20 0.33
PSENEN Q9NZ42 5/20 0.33
PTPN1 P18031 1/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
USP2 O75604 1/20 0.32
PKM P14618 1/20 0.32
DPP4 P27487 1/20 0.31
DPP8 Q6V1X1 1/20 0.31
DPP9 Q86TI2 1/20 0.31
DPP7 Q9UHL4 1/20 0.31
HTR1A P08908 1/20 0.31
DRD2 P14416 1/20 0.31
HTR7 P34969 1/20 0.31
HTR6 P50406 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8730063 0.87 PSEN1 (0.34) KAT6AKDM4EPSEN1PSEN2APH1B
SCHEMBL8732898 0.86 PSEN1 (0.33) KAT6AKDM4EPSEN1PSEN2APH1B
SCHEMBL8729962 0.84 KAT6A (0.35) KAT6AKDM4EPSEN1PSEN2APH1B
SCHEMBL8732824 0.84 SMN1; SMN2 (0.34) KAT6AKDM4EPSEN1PSEN2APH1B
SCHEMBL8735692 0.80
SCHEMBL8735760 0.80
SCHEMBL9070015 0.78 PDE2A (0.39) DPP7
SCHEMBL8734764 0.78
SCHEMBL9069741 0.77 ALDH1A1 (0.32) KAT6APKM
SCHEMBL8729859 0.77 KAT6A (0.38) KAT6AKDM4EPTPN1SMN1; SMN2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699390-B1 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM & HAAS (US) 1998-10-07 EP claimed
US-5500405-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1996-03-19 US claimed