SCHEMBL8735781

SCHEMBL8735781

COC(=O)Cc1ccc(CCN)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.70
CYP4A11 Q02928 1/20 0.70
ALDH1A1 P00352 4/20 0.53
GAA P10253 1/20 0.53
GFER P55789 1/20 0.53
TAAR1 Q96RJ0 5/20 0.52
HSP90AB1 P08238 1/20 0.48
MAOB P27338 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2A6 P11509 1/20 0.47
KDM4E B2RXH2 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
SLC6A2 P23975 1/20 0.47
CYP2C19 P33261 1/20 0.47
HTR3A P46098 1/20 0.47
BACE1 P56817 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.45
NPC1 O15118 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9335479 0.98 CYP4F2 (0.68) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL5843409 0.89 CYP4A11 (0.66) CYP4F2CYP4A11ALDH1A1GAAGFER
Hydrochloric Acid SCHEMBL5843402 0.87 CYP4A11 (0.64) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL11131179 0.86 CYP4A11 (0.62) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL4113212 0.85 CYP4F2 (0.76) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL26517824 0.85 TAAR1 (0.52) CYP4F2CYP4A11ALDH1A1TAAR1MAOB
SCHEMBL11493064 0.84 CYP4A11 (0.75) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL4066292 0.84 CYP4F2 (0.63) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL15586041 0.84 CYP4A11 (0.75) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL1161121 0.84 CYP4F2 (0.63) CYP4F2CYP4A11ALDH1A1GAAGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479840-B2 HMG-CoA reductase degradation inducing compound UPPTHERA INC. (KR) 2025-11-25 US disclosed
US-20230078961-A1 HMG-CoA Reductase Degradation Inducing Compound UPPTHERA INC. (KR) 2023-03-16 US disclosed
WO-2021201577-A1 HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND UPPTHERA (KR) 2021-10-07 WO disclosed
EP-3362454-A1 EP4 ANTAGONISTS Eisai R&D Management Co., Ltd. (JP) 2018-08-22 EP disclosed
WO-2017066633-A1 EP4 ANTAGONISTS EISAI R&D MANAGEMENT CO., LTD. (JP) 2017-04-20 WO disclosed
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 EP disclosed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230078961-A1 HMG-CoA Reductase Degradation Inducing Compound HMGCR, HMGB2, LDLR CYP4F2 378/4885CYP4A11 118/4885ALDH1A1 1022/4885
US-12479840-B2 HMG-CoA reductase degradation inducing compound HMGCR, HMGB2, LDLR CYP4F2 378/4885CYP4A11 118/4885ALDH1A1 1022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.