Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736115 | 0.99 | ABCB11 (0.55) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL8735812 | 0.97 | ABCB11 (0.56) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL2720979 | 0.93 | ABCB11 (0.54) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL8735816 | 0.93 | ABCB11 (0.57) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL2722099 | 0.92 | ABCB11 (0.55) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL2720983 | 0.90 | ABCB11 (0.56) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| Hydrochloric Acid SCHEMBL29287967 | 0.89 | ABCB11 (0.56) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL19563372 | 0.89 | ABCB11 (0.54) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL2721130 | 0.89 | ABCB11 (0.54) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 | |
| SCHEMBL8737219 | 0.88 | ABCB11 (0.55) | ABCB11CYP2C19OPRM1ADRA2ACYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180064718-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | ABIONYX PHARMA (FR) | 2018-03-08 | — | — | US | disclosed |
| US-9757381-B2 | Compounds, compositions and methods useful for cholesterol mobilization | CERENIS THERAPEUTICS HOLDING SA (FR) | 2017-09-12 | — | — | US | disclosed |
| US-9713619-B2 | Compounds, compositions and methods useful for cholesterol mobilization | CERENIS THERAPEUTICS HOLDING SA (FR) | 2017-07-25 | — | — | US | disclosed |
| US-20160361318-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CERENIS THERAPEUTICS HOLDING SA (FR) | 2016-12-15 | — | — | US | disclosed |
| US-20150344455-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CERENIS THERAPEUTICS HOLDING SA (FR) | 2015-12-03 | — | — | US | disclosed |
| US-9085585-B2 | Compounds, compositions and methods useful for cholesterol mobilization | CERENIS THERAPEUTICS HOLDING SA (FR) | 2015-07-21 | — | — | US | disclosed |
| US-20130267554-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CERENIS THERAPEUTICS HOLDING SA (FR) | 2013-10-10 | — | — | US | disclosed |
| US-20120129856-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILISATION | CERENIS THERAPEUTICS SA (FR) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180064718-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CETP, LIPA, NPC1L1 | ABCB11 31/4885CYP2C19 1577/4885OPRM1 3438/4885 |
| US-20120129856-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILISATION | CETP, NPC1L1, NPC1 | ABCB11 9/4885CYP2C19 689/4885OPRM1 4159/4885 |
| US-20150344455-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CETP, LIPA, NPC1L1 | ABCB11 31/4885CYP2C19 1577/4885OPRM1 3438/4885 |
| US-20130267554-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CETP, LIPA, NPC1L1 | ABCB11 31/4885CYP2C19 1577/4885OPRM1 3438/4885 |
| US-20160361318-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILIZATION | CETP, LIPA, NPC1L1 | ABCB11 31/4885CYP2C19 1577/4885OPRM1 3438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.