Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9167795 | 0.95 | PSMB5 (0.46) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL10788453 | 0.93 | PSMB5 (0.44) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL1243063 | 0.83 | KDM4E (0.41) | PSMB5PTGDR2NR1I2KDM4BCHRM1 | |
| SCHEMBL533769 | 0.83 | CYP3A4 (0.44) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL9785309 | 0.83 | NUDT1 (0.44) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL1245161 | 0.80 | NUDT1 (0.45) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL11324503 | 0.80 | NUDT1 (0.41) | PSMB5PTGDR2NR1I2KDM4BCHRM1 | |
| SCHEMBL533099 | 0.80 | CYP3A4 (0.46) | PSMB5JAK2JAK1TYK2JAK3 | |
| SCHEMBL11705549 | 0.80 | KDM4E (0.38) | PSMB5PTGDR2NR1I2KDM4BCHRM1 | |
| SCHEMBL1186506 | 0.79 | NUDT1 (0.44) | PSMB5JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706987-B1 | Process for preparing alkylated aromatic carboxylic acids and carboxylic acid halogenides | CIBA GEIGY AG (CH) | 1998-06-03 | — | — | EP | disclosed |
| US-5616787-A | REACTING THE CORRESPONDING AROMATIC HYDROCARBON WITH CARBON DIOXIDE | CIBA-GEIGY CORPORATION (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0706987-A1 | Process for preparing alkylated aromatic carboxylic acids and carboxylic acids halogenides | CIBA-GEIGY AG (CH) | 1996-04-17 | — | — | EP | disclosed |