SCHEMBL8736640

SCHEMBL8736640

Cc1c(Br)c(C)c2cccc(C)c2c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.44
CYP2A6 P11509 3/20 0.44
ALDH1A1 P00352 4/20 0.38
AHR P35869 1/20 0.36
ESR2 Q92731 2/20 0.33
ATM Q13315 2/20 0.33
GPR84 Q9NQS5 1/20 0.33
TRPA1 O75762 1/20 0.33
TSHR P16473 3/20 0.32
HPGD P15428 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
CASP1 P29466 1/20 0.32
RAB9A P51151 1/20 0.32
CASP7 P55210 1/20 0.32
HIF1A Q16665 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31374647 0.81 CYP1A2 (0.52) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL2300447 0.81 CYP1A2 (0.52) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL10434554 0.81 CYP1A2 (0.58) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL20375922 0.75 TSHR (0.56) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL9623184 0.74 ALDH1A1 (0.48) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL30620970 0.73 CYP1A2 (0.48) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL4647911 0.71 CYP1A2 (0.46) CYP1A2CYP2A6ALDH1A1AHRGPR84
SCHEMBL11826117 0.70 CYP1A2 (0.44) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL16029928 0.70 CYP2A6 (0.44) CYP1A2CYP2A6ALDH1A1AHRESR2
SCHEMBL11057887 0.70 ALDH1A1 (0.48) CYP1A2CYP2A6ALDH1A1AHRESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832057-A1 DIAROMATIC PROPYNYL OR DIENYL COMPOUNDS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-04-01 EP disclosed
WO-1997033856-A1 DIAROMATIC PROPYNYL OR DIENYL COMPOUNDS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1997-09-18 WO disclosed