Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6116806 | 0.91 | P2RY12 (0.47) | P2RY12HASPINMAPTCCNT1CDK1 | |
| SCHEMBL8737668 | 0.81 | S1PR1 (0.45) | P2RY12MAPTMEN1KMT2APOLB | |
| SCHEMBL6115973 | 0.77 | S1PR1 (0.43) | MAPTLMNA | |
| SCHEMBL6115727 | 0.76 | P2RY12 (0.45) | P2RY12LMNAPDE10A | |
| SCHEMBL6117360 | 0.75 | P2RY12 (0.43) | P2RY12MEN1KMT2APOLBLMNA | |
| SCHEMBL8738758 | 0.72 | S1PR1 (0.47) | P2RY12LMNA | |
| SCHEMBL9290613 | 0.71 | CACNA1G (0.37) | POLB | |
| SCHEMBL6116102 | 0.68 | S1PR1 (0.44) | MAPT | |
| SCHEMBL6116492 | 0.67 | MEN1 (0.48) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL6116209 | 0.67 | S1PR1 (0.45) | MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | S1PR1, S1PR3, S1PR2 | P2RY12 332/4885HASPIN 438/4885MAPT 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.