Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 5/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737484 | 0.83 | LMNA (0.36) | LMNAPDE1APDE1BPDE1CPSEN1 | |
| SCHEMBL13057230 | 0.76 | PSEN1 (0.46) | KCNH2PDE1APDE1BPDE1CPSEN1 | |
| SCHEMBL6124260 | 0.73 | TSHR (0.44) | LMNACRHR1PSEN1PSEN2APH1B | |
| SCHEMBL6127801 | 0.69 | KDM4E (0.47) | LMNAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23288646 | 0.68 | KCNH2 (0.34) | KCNH2PDE1APDE1BPDE1C | |
| SCHEMBL23244929 | 0.66 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL15290433 | 0.66 | PSEN1 (0.38) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6124263 | 0.66 | PCSK9 (0.31) | — | |
| SCHEMBL16202004 | 0.64 | NQO1 (0.48) | LMNA | |
| SCHEMBL12257634 | 0.64 | PSEN1 (0.40) | KCNH2LMNAPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426595-B2 | Gamma secretase modulators | MERCK SHARP & DOHME LLC | 2013-04-23 | — | — | US | disclosed |
| US-20120129846-A1 | GAMMA SECRETASE MODULATORS | Merck, Sharp & Dohme, Corp. | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129846-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | KCNH2 4062/4885LMNA 652/4885PDE1A 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.