Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120173 | 0.91 | EZH2 (0.77) | EZH2SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL8739377 | 0.90 | EZH2 (0.78) | EZH2MRGPRX4L3MBTL1MEN1KMT2A | |
| SCHEMBL8738985 | 0.86 | EZH2 (0.58) | EZH2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8738583 | 0.86 | EZH2 (0.62) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739008 | 0.84 | EZH2 (0.56) | EZH2SMN1; SMN2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8738289 | 0.82 | EZH2 (0.69) | EZH2MRGPRX4L3MBTL1MEN1KMT2A | |
| SCHEMBL8739225 | 0.80 | EZH2 (0.78) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL6121036 | 0.80 | EZH2 (0.78) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738955 | 0.79 | MEN1 (0.69) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739015 | 0.79 | EZH2 (0.77) | EZH2L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |