Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739377 | 0.89 | EZH2 (0.78) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738149 | 0.88 | EZH2 (0.76) | EZH2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL8738140 | 0.86 | EZH2 (0.63) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738289 | 0.84 | EZH2 (0.69) | EZH2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL6121036 | 0.83 | EZH2 (0.78) | EZH2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL8738955 | 0.81 | MEN1 (0.69) | EZH2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL8739031 | 0.80 | EZH2 (0.70) | EZH2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6236678 | 0.80 | L3MBTL1 (0.67) | EZH2POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL8738695 | 0.79 | EZH2 (0.91) | EZH2 | |
| SCHEMBL310763 | 0.79 | KMT2A (0.82) | EZH2POLBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |