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SCHEMBL8738202

SCHEMBL8738202

COc1ccc(Oc2ccc(C(=O)NC3CC(C)(C)NC(C)(C)C3)cc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 12/20 0.81
▸ ATM Q13315 1/20 0.68
▸ L3MBTL1 Q9Y468 1/20 0.68
▸ MEN1 O00255 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ PKM P14618 1/20 0.60
▸ GLA P06280 1/20 0.57
▸ POLB P06746 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17067308 0.96 EZH2 (0.74) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738134 0.91 EZH2 (0.80) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738111 0.90 EZH2 (0.81) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738240 0.90 EZH2 (0.81) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL6120964 0.90 EZH2 (1.00) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738313 0.88 EZH2 (0.79) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738545 0.88 EZH2 (0.79) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738108 0.88 EZH2 (0.79) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8739359 0.87 EZH2 (0.77) EZH2ATML3MBTL1MEN1KMT2A
SCHEMBL8738144 0.87 EZH2 (1.00) EZH2ATML3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012068589-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2012-05-24 — — WO disclosed