Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 13/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120964 | 0.88 | EZH2 (1.00) | EZH2L3MBTL1ATMGLAMEN1 | |
| SCHEMBL8738111 | 0.88 | EZH2 (0.81) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738202 | 0.88 | EZH2 (0.81) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738240 | 0.88 | EZH2 (0.81) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738108 | 0.87 | EZH2 (0.79) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738545 | 0.87 | EZH2 (0.79) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738197 | 0.87 | EZH2 (0.78) | EZH2L3MBTL1 | |
| SCHEMBL8739359 | 0.86 | EZH2 (0.77) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8739064 | 0.85 | EZH2 (0.76) | EZH2L3MBTL1ATMGLAPOLB | |
| SCHEMBL8738644 | 0.85 | EZH2 (0.81) | EZH2L3MBTL1ATMGLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |