Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738999 | 0.83 | KMT2A (0.59) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8739686 | 0.79 | KMT2A (0.57) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8739391 | 0.79 | KMT2A (0.56) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8739672 | 0.79 | MEN1 (0.61) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8739201 | 0.78 | HDAC1 (0.61) | MEN1KMT2AEZH2HTT | |
| SCHEMBL8738151 | 0.76 | MEN1 (0.57) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8739223 | 0.75 | MEN1 (0.56) | MEN1KMT2AEZH2GLATP53 | |
| SCHEMBL8738166 | 0.74 | MEN1 (0.60) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL8738120 | 0.74 | MEN1 (0.60) | MEN1KMT2AEZH2GLAL3MBTL1 | |
| SCHEMBL6120920 | 0.73 | MEN1 (0.77) | MEN1KMT2AEZH2GLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |