Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | IDO1 | P14902 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302839 | 0.82 | HDAC1 (0.67) | HDAC1HDAC6HRH3IDO1LMNA | |
| SCHEMBL8738652 | 0.78 | MEN1 (0.57) | EZH2HTTMEN1KMT2A | |
| SCHEMBL12850040 | 0.77 | HDAC6 (1.00) | HDAC1HDAC6IDO1LMNACYP11B1 | |
| Tert-Butyl Formate SCHEMBL27786473 | 0.76 | HDAC1 (0.53) | HDAC1HDAC6HRH3IDO1LMNA | |
| SCHEMBL8738670 | 0.76 | EZH2 (0.74) | EZH2MEN1KMT2A | |
| SCHEMBL6120593 | 0.76 | EZH2 (0.74) | EZH2MEN1KMT2A | |
| SCHEMBL3725969 | 0.76 | HDAC1 (0.55) | HDAC1HDAC6HRH3LMNAMEN1 | |
| SCHEMBL28787442 | 0.76 | HDAC1 (0.52) | HDAC1HDAC6HRH3IDO1LMNA | |
| SCHEMBL8738903 | 0.75 | EZH2 (0.53) | EZH2MEN1KMT2A | |
| SCHEMBL169747 | 0.75 | EZH2 (0.80) | EZH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |